The Swedish Human Proteome Resource (HPR) Center is located at the AlbaNova University center at the Royal Institute of Technology, Stockholm and at the Rudbeck Laboratory, Uppsala University, Uppsala. The Stockholm site is responsible for generating high-quality monospecific antibodies, and the Uppsala site is responsible for large-scale protein profiling in tissues and cells. The Research Groups of the consortium are divided into ten modules, each responsible for a specific part of the program. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). The antibodies are subsequently used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of assay platforms. The vision is to systematically generate quality assured antibodies to all non-redundant human proteins, and to use these reagents to functionally explore human proteins, protein variants and protein interactions. The Swedish Human Protein Atlas (HPA) program has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified (mono-specific) antibodies with protein profiling in a multitude of tissues/celltypes assembled in tissue microarrays. The program is run by Proteome Resource (HPR) Center located in Stockholm and Uppsala, Sweden. The Swedish Human Protein Atlas (HPA) program, funded by the Knut and Alice Wallenberg Foundation.
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Time period: 2002-01-01 - 2010-12-31 URL: Webpage |